Research
Clinical trials
Every amyloidosis study now recruiting, about to open, or enrolling by invitation, anywhere in the world, listed straight from ClinicalTrials.gov and refreshed every day.
Information, not medical advice. The Alliance does not run these studies and cannot enrol you in one. If a trial looks relevant, discuss it with the doctor who follows your amyloidosis.
Recruiting and upcoming studies
The list covers AL, ATTR and AA amyloidosis as well as cerebral amyloid angiopathy. Each card says where the study stands: open to anyone who meets its criteria, not yet open, or restricted to people the investigators invite. Studies that close simply leave the list.
Showing 169–180 of 202 trials
RecruitingATTR (transthyretin)
Prevalence of Wild-type TTR Cardiac Amyloidosis in Patients With Polyneuropathy of Unknown Cause. (opens on ClinicalTrials.gov)
To investigate to what extent chronic axonal length-dependent polyneuropathy (CAP) and/or small-fiber neuropathy (SFN) is part of early non-cardiac manifestations of wild-type TTR cardiac…
- Study
- Interventional (treatment)
- Sponsor
- Universitair Ziekenhuis Brussel
Recruiting in: Belgium
NCT05950867Updated 22 July 2025
Not yet recruitingAL (light chain)
Study of Eque-cel CAR-T Therapy in Newly Diagnosed Severe AL Amyloidosis (opens on ClinicalTrials.gov)
The goal of this clinical trial is to learn if Equecabtagene Autoleucel(Eque-cel), a Chimeric Antigen Receptor T-cell (CAR-T) therapy, works to treat severe Light…
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- Nanjing IASO Biotechnology Co., Ltd.
No study locations listed yet
NCT07055724Updated 9 July 2025
RecruitingCerebral amyloid angiopathy
Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage (opens on ClinicalTrials.gov)
The goal of this clinical trial is to assess the safety and tolerability of colchicine for preventing intracerebral haemorrhage (ICH) recurrence in patients with…
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- Huashan Hospital
Recruiting in: China
NCT07026994Updated 26 June 2025
RecruitingATTR (transthyretin)
Exercise in Hereditary ATTR (ATTRv) Amyloidosis (opens on ClinicalTrials.gov)
This study aims to explore the effects of a 12-week exercise intervention on the physical and mental health of people living with Hereditary ATTR…
- Study
- Interventional (treatment)
- Sponsor
- University of Maia
Recruiting in: Portugal
NCT07033715Updated 24 June 2025
RecruitingATTR (transthyretin)
Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathy (opens on ClinicalTrials.gov)
This Phase 1b/2a study aims to investigate the safety and efficacy of genistein in patients with Transthyretin (TTR) Amyloidosis. The focus is on its…
- Study
- Interventional (treatment)
- Phase
- Phase 1
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Recruiting in: Canada
NCT06634108Updated 15 June 2025
RecruitingAL (light chain)
Teclistamab in Previously Treated AL Amyloidosis (opens on ClinicalTrials.gov)
This is a phase II study in patients with previously treated immunoglobulin light-chain (AL) Amyloidosis to evaluate the efficacy and safety of teclistamab
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- Peking Union Medical College Hospital
Recruiting in: China
NCT06935162Updated 25 May 2025
Not yet recruitingNot specified
MCLENA-2: A Phase II Clinical Trial for the Assessment of Lenalidomide in Patients With Mild Cognitive Impairment (opens on ClinicalTrials.gov)
This is a randomized, double-blind, placebo-controlled, parallel group study. The use of placebo is appropriate to minimize bias related to treatment expectations of the…
- Study
- Interventional (treatment)
- Phase
- Phase 2
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
No study locations listed yet
NCT06177028Updated 18 May 2025
RecruitingATTR (transthyretin)
Thailand ATTR-CM Registry (opens on ClinicalTrials.gov)
The investigators of this registry aim to study the natural history, clinical presentation, characteristics, and imaging findings of patients diagnosed with ATTR amyloidosis in…
- Study
- Observational (registry, imaging)
- Sponsor
- Mahidol University
Recruiting in: Thailand
NCT06338696Updated 8 May 2025
RecruitingAL (light chain)
Prospective Study of Teclistamab in the Treatment of Systemic AL Amyloidosis (opens on ClinicalTrials.gov)
This study aims to evaluate the use of teclistamab in systemic AL amyloidosis and answer whether teclistamab can improve the rate of complete hematological…
- Study
- Interventional (treatment)
- Sponsor
- Peking University People's Hospital
Recruiting in: China
NCT06699394Updated 24 April 2025
RecruitingATTR (transthyretin)
An Interventional Pilot Study to Investigate the Feasibility and Acceptance of a Structured Psychological Support Program for Patients, Caregivers, and Presymptomatic Carriers in Hereditary Transthyretin Amyloidosis With Cardiomyopathy (opens on ClinicalTrials.gov)
Hereditary transthyretin amyloidosis (ATTRv) is a genetic, progressive and disabling disease that affects multiple organs and severely compromises the quality of life of patients…
- Study
- Interventional (treatment)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting in: Italy
NCT06907186Updated 6 April 2025
RecruitingATTR (transthyretin)
Description of a Retrospective Cohort of Patients With Transthyretin Cardiac Amyloidosis (ATTR-CA) in Internal Medicine (opens on ClinicalTrials.gov)
In 2024, the prevalence of TTR cardiac amyloidosis is difficult to determine precisely. Indeed, the disease has long been underdiagnosed due to a lack…
- Study
- Observational (registry, imaging)
- Sponsor
- University Hospital, Strasbourg, France
Recruiting in: France
NCT06907836Updated 2 April 2025
RecruitingNot specified
International Cardiac Amyloidosis Registry (opens on ClinicalTrials.gov)
Cardiac amyloidosis is a relatively rare disease. However, with the newer imaging techniques that have become available to us in recent years, determining the…
- Study
- Observational (registry, imaging)
- Sponsor
- Leiden University Medical Center
Recruiting in: BelgiumItalyJapanNetherlands+1
NCT06894290Updated 25 March 2025
This list only covers amyloidosis studies that are open or about to open. The registry holds every study, including those already completed.
Source: ClinicalTrials.gov (U.S. National Library of Medicine). List last retrieved on 7 November 2026. clinicaltrials.gov
Not sure where to start?
Our member associations know the teams running these studies in their own country, and can help you prepare the conversation with your doctor.