Research
Clinical trials
Every amyloidosis study now recruiting, about to open, or enrolling by invitation, anywhere in the world, listed straight from ClinicalTrials.gov and refreshed every day.
Information, not medical advice. The Alliance does not run these studies and cannot enrol you in one. If a trial looks relevant, discuss it with the doctor who follows your amyloidosis.

Recruiting and upcoming studies
The list covers AL, ATTR and AA amyloidosis as well as cerebral amyloid angiopathy. Each card says where the study stands: open to anyone who meets its criteria, not yet open, or restricted to people the investigators invite. Studies that close simply leave the list.
Showing 109–120 of 202 trials
RecruitingNot specified
Repeat PET/CT Imaging in People With CAPS and Anakinra-Induced Amyloidosis Using an Amyloid-Reactive Peptide to Measure Changes in Organ-Specific Amyloid Load (opens on ClinicalTrials.gov)
Background: Anakinra is a drug used to treat people with certain diseases that affect their immune systems. Sometimes anakinra can cause proteins under the…
- Study
- Interventional (treatment)
- Phase
- Phase 1
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting in: United States
NCT06974877Updated 19 May 2026
Not yet recruitingATTR (transthyretin)
Retrospective Identification of Scintigraphic Cardiac Amyloidosis (RISCA) (opens on ClinicalTrials.gov)
This study aims to determine the positive predictive value of incidental cardiac uptake on bone scintigraphy for diagnosing transthyretin cardiac amyloidosis, in patients who…
- Study
- Observational (registry, imaging)
- Sponsor
- University Hospital, Lille
No study locations listed yet
NCT06921408Updated 15 May 2026
RecruitingAL (light chain)
A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion (opens on ClinicalTrials.gov)
Immunoglobulin light chain (AL) amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis has many root causes and is characterized by the…
- Study
- Interventional (treatment)
- Phase
- Phase 1
- Sponsor
- AbbVie
Recruiting in: AustraliaFranceGreeceItaly+2
NCT06158854Updated 13 May 2026
Not yet recruitingNot specified
Early Screening for Cardiac Amyloid Using a History of Bilateral Carpal Tunnel Syndrome (opens on ClinicalTrials.gov)
Cardiac amyloidosis is a condition where abnormal protein deposits build up in the heart, making it stiff and causing it to work less effectively.…
- Study
- Interventional (treatment)
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
No study locations listed yet
NCT07580872Updated 12 May 2026
Not yet recruitingNot specified
Screening, Characterization, and Longitudinal Follow-up of Patients With Cardiac Amyloidosis (opens on ClinicalTrials.gov)
Cardiac amyloidosis is a progressive disorder caused by extracellular deposition of amyloid fibrils in the heart, leading to heart failure and impaired cardiac function.…
- Study
- Observational (registry, imaging)
- Sponsor
- Heinrich-Heine University, Duesseldorf
Recruiting in: Germany
NCT07577466Updated 11 May 2026
RecruitingAL (light chain)
Assessment of the Efficacy and Safety of Injectable TQB2934 (Subcutaneous Injection) in Systemic Light Chain Amyloidosis Patients (opens on ClinicalTrials.gov)
This study is a clinical trial aimed at the marketing of TQB2934 for injection. The project plans to enroll 70 subjects, including 13-21 subjects…
- Study
- Interventional (treatment)
- Phase
- Phase 1
- Sponsor
- Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd.
Recruiting in: China
NCT07266116Updated 8 May 2026
RecruitingAL (light chain)
Comparing Dara-VCD Chemotherapy Plus Stem Cell Transplant to Dara-VCD Chemotherapy Alone for People Who Have Newly Diagnosed AL Amyloidosis (opens on ClinicalTrials.gov)
This phase III trial compares the effect of adding a stem cell transplant with melphalan after completing chemotherapy with daratumumab, cyclophosphamide, bortezomib and dexamethasone…
- Study
- Interventional (treatment)
- Phase
- Phase 3
- Sponsor
- SWOG Cancer Research Network
Recruiting in: United States
NCT06022939Updated 6 May 2026
RecruitingAL (light chain)
One Gene, Two Diseases: the Pathologic Role of IGLV1-44 in AL Amyloidosis and POEMS (opens on ClinicalTrials.gov)
By detailed sequence analysis and subsequent biophysical characterization of prototypic light chains, this project aims to identify sequence fingerprints in IGLV1-44 light chains leading…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting in: Italy
NCT07448935Updated 6 May 2026
Not yet recruitingNot specified
Early Detection of Concealed Cardiac Amyloidosis Using AI-ECG and CT-Derived Extracellular Volume in Patients With Atrial Fibrillation (opens on ClinicalTrials.gov)
This study investigates the clinical efficacy of a non-invasive screening protocol using AI-ECG and CT-ECV analysis for cardiac amyloidosis. The study targets on atrial…
- Study
- Interventional (treatment)
- Sponsor
- Samsung Medical Center
Recruiting in: South Korea
NCT07567508Updated 5 May 2026
RecruitingNot specified
Cardiac Amyloidosis pRevaleNce of in OLDer Subjects Affected by Heart Failure (opens on ClinicalTrials.gov)
Tne aim purpose of this observational, multicentre and propective study is to determine the prevalence of cardiac amyloidosis in geriatric patients aged 80 years…
- Study
- Observational (registry, imaging)
- Sponsor
- Gérond'if
Recruiting in: France
NCT06427304Updated 20 April 2026
Enrolling by invitationATTR (transthyretin)
An Extension Study to Assess Long-Term Safety of Eplontersen in Adults With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR-CM) (opens on ClinicalTrials.gov)
The purpose of this study is to evaluate the safety and tolerability of extended dosing with eplontersen in participants with ATTR-CM.
- Study
- Interventional (treatment)
- Phase
- Phase 3
- Sponsor
- Ionis Pharmaceuticals, Inc.
Recruiting in: ArgentinaAustraliaAustriaBelgium+16
NCT05667493Updated 17 April 2026
RecruitingAL (light chain)
A EUropean REgistry and Sample Sharing networK to Promote the Diagnosis and Management of Light Chain Amyloidosis (EUREKA) (opens on ClinicalTrials.gov)
A prospective patients' registry collecting all new cases of AL amyloidosis evaluated at referral Centers from across Europe and a sample sharing network will…
- Study
- Observational (registry, imaging)
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Recruiting in: GermanyItalyNetherlandsSpain+2
NCT06205953Updated 16 April 2026
This list only covers amyloidosis studies that are open or about to open. The registry holds every study, including those already completed.
Source: ClinicalTrials.gov (U.S. National Library of Medicine). List last retrieved on 7 November 2026. clinicaltrials.gov
Not sure where to start?
Our member associations know the teams running these studies in their own country, and can help you prepare the conversation with your doctor.